API-5 polyclonal, anti-human, mouse, rat
€347.00
In stock
SKU
251620
Catalog Nr.: 251620
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IP
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IP
Protein Family: Chaperones and Folding Catalysts
Pathway and Disease: Signaling Molecules and Interaction, Cell Growth and Death
Description:
Apoptosis inhibitor 5 (API-5) is an antiapoptotic factor that plays a role in protein assembly. API-5 negatively regulates ACIN1. By binding to ACIN1, API-5 suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. API-5 also efficiently suppresses E2F1-induced apoptosis. Low levels of API-5 enhance the cytotoxic action of the chemotherapeutic drugs.
Alternate Names: API-5, Apoptosis inhibitor 5, Fibroblast growth factor 2-interacting factor, FIF, Protein XAGL, Antiapoptosis clone 11 protein, AAC-11, Cell migration-inducing gene 8 protein, API5, MIG8
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500
Accession No.: Q9BZZ5
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human protein API-5 .
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Cell Growth and Death
Description:
Apoptosis inhibitor 5 (API-5) is an antiapoptotic factor that plays a role in protein assembly. API-5 negatively regulates ACIN1. By binding to ACIN1, API-5 suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. API-5 also efficiently suppresses E2F1-induced apoptosis. Low levels of API-5 enhance the cytotoxic action of the chemotherapeutic drugs.
Alternate Names: API-5, Apoptosis inhibitor 5, Fibroblast growth factor 2-interacting factor, FIF, Protein XAGL, Antiapoptosis clone 11 protein, AAC-11, Cell migration-inducing gene 8 protein, API5, MIG8
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500
Accession No.: Q9BZZ5
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human protein API-5 .
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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