Apo-E polyclonal, anti-mouse, rat
€378.00
In stock
SKU
250544
Catalog Nr.: 250544
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Transporters
Pathway and Disease: Lipid Metabolism, Neurodegenerative Disorders, Signaling Molecules and Interaction; Endocrine System
Description:
Apolipoprotein E (Apo-E) is a protein component of plasma lipoprotein that mediates the binding, internalization and catabolism of lipoprotein particles. Apo-E can serve as a ligand for the LDL (Apo-B/E) receptor and for the specific Apo-E receptor (chylomicron remnant) of hepatic tissues. Apo-E is present in all lipoprotein fractions in plasma and constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL) . Apo-E is produced in most organs. Defects in Apo-E are a cause of hyperlipoproteinemia type III (lipid deposits in palms, tendons and elbows), sea-blue histiocyte disease (splenomegaly, thrombocytopenia), and lipoprotein glomerulopathy.
Alternate Names: Apolipoprotein E, Apo-E, APOE
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P02649
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of mouse Apo-E.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Lipid Metabolism, Neurodegenerative Disorders, Signaling Molecules and Interaction; Endocrine System
Description:
Apolipoprotein E (Apo-E) is a protein component of plasma lipoprotein that mediates the binding, internalization and catabolism of lipoprotein particles. Apo-E can serve as a ligand for the LDL (Apo-B/E) receptor and for the specific Apo-E receptor (chylomicron remnant) of hepatic tissues. Apo-E is present in all lipoprotein fractions in plasma and constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL) . Apo-E is produced in most organs. Defects in Apo-E are a cause of hyperlipoproteinemia type III (lipid deposits in palms, tendons and elbows), sea-blue histiocyte disease (splenomegaly, thrombocytopenia), and lipoprotein glomerulopathy.
Alternate Names: Apolipoprotein E, Apo-E, APOE
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P02649
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of mouse Apo-E.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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