APOE Antibody (C-term) Blocking Peptide

APOE Antibody (C-term) Blocking Peptide

€293.00
In stock
SKU
AC-BP7587b
Catalog Number: AC-BP7587b
Size: 500 µg
Datasheet

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Background:
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III),in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Other Names: Apolipoprotein E, Apo-E, APOE

Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7587b was selected from the C-term region of human APOE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Type: Synthetic peptide

Primary Accession: P02649

Gene ID: 348

Gene Name: APOE

Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Bio References:
Wood,K.C., Appl Physiol Nutr Metab 33 (4), 761-768 (2008)Pemberton,L., (er) HIV Med. (2008) In pressSundermann,E.E., (er) Horm Behav (2008) In pressChristensen,H.,(er) BMC Geriatr 8, 14 (2008)
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