APP/β-Amyloid (phospho-T668) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4214
Background:
Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the β-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer’s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid β/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer’s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP.
Alternative Name:
Amyloid beta A4 protein, ABPP, APPI, Short name=APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Short name=CVAP, PreA4, Protease nexin-II, Short name=PN-II, N-APP, Soluble APP-alpha, Short name=S-APP-alpha, Soluble APP-beta, Short name=S-APP-beta, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, P3(42), P3(40), Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, Short name=AICD-59, Short name=AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, Short name=AICD-57, Short name=AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), APP, A4, AD, Amyloid-β, Amyloid β, Amyloidβ, β Amyloid, βAmyloid, Aβ
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-APP/β-Amyloid (T668) polyclonal antibody detects endogenous levels of APP695 protein only when phosphorylated at Thr668 (or the corresponding position on other isoforms).
Immunogen:
Synthetic phosphopeptide derived from human APP/β-Amyloid around the phosphorylation site of Threonine 668.
MW: ~ 70 to140 kDa
Swis Prot.: P05067
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the β-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer’s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid β/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer’s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP.
Alternative Name:
Amyloid beta A4 protein, ABPP, APPI, Short name=APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Short name=CVAP, PreA4, Protease nexin-II, Short name=PN-II, N-APP, Soluble APP-alpha, Short name=S-APP-alpha, Soluble APP-beta, Short name=S-APP-beta, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, P3(42), P3(40), Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, Short name=AICD-59, Short name=AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, Short name=AICD-57, Short name=AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), APP, A4, AD, Amyloid-β, Amyloid β, Amyloidβ, β Amyloid, βAmyloid, Aβ
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-APP/β-Amyloid (T668) polyclonal antibody detects endogenous levels of APP695 protein only when phosphorylated at Thr668 (or the corresponding position on other isoforms).
Immunogen:
Synthetic phosphopeptide derived from human APP/β-Amyloid around the phosphorylation site of Threonine 668.
MW: ~ 70 to140 kDa
Swis Prot.: P05067
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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