APS Antibody (Y629) Blocking Peptide
€293.00
In stock
SKU
AC-BP7747a
Background:
APS is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.
Other Names: SH2B adapter protein 2, Adapter protein with pleckstrin homology and Src homology 2 domains, SH2 and PH domain-containing adapter protein APS, SH2B2, APS
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7747a was selected from the Y629 region of human APS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: O14492
Gene ID: 10603
Gene Name: SH2B2
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Li,M., Endocrinology 148 (4), 1615-1621 (2007)Katsanakis,K.D., J. Biol. Chem. 280 (45), 37827-37832 (2005)Iseki,M., Biochem. Biophys. Res. Commun. 330 (3), 1005-1013 (2005)
APS is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.
Other Names: SH2B adapter protein 2, Adapter protein with pleckstrin homology and Src homology 2 domains, SH2 and PH domain-containing adapter protein APS, SH2B2, APS
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7747a was selected from the Y629 region of human APS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: O14492
Gene ID: 10603
Gene Name: SH2B2
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Li,M., Endocrinology 148 (4), 1615-1621 (2007)Katsanakis,K.D., J. Biol. Chem. 280 (45), 37827-37832 (2005)Iseki,M., Biochem. Biophys. Res. Commun. 330 (3), 1005-1013 (2005)
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