AQP2 polyclonal, anti-human, mouse

Protein Family: Receptors and Channels

Pathway and Disease: Metabolic Disorders

Description:
Aquaporin-2 (AQP-2) forms a water specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. It is expressed in the renal collecting tubules. Defects in AQP2 are a cause of autosomal recessive nephrogenic diabetes insipidus (ANDI), also known as diabetes insipidus nephrogenic type 2. It is characterized by excessive water drinking (polydypsia) and urine excretion (polyuria). Belongs to the MIP/aquaporin (TC1.A.8) family.

Alternate Names: Aquaporin-2, AQP2, Aquaporin protein-2, AQP-2, Aquaporin-CD, AQP-CD, Water channel protein for renal collecting duct, ADH water channel, Collecting duct water channel protein, WCH-CD

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P41181

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Aquaporin-2.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.