AQP2 (Ser269) polyclonal, anti-mouse , bovine, dog
€440.00
In stock
SKU
252523
Catalog Nr.: 252523
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB
Protein Family: Receptors and Channels
Pathway and Disease: Metabolic Disorders
Description:
Aquaporin-2 (AQP-2) forms a water specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. It is expressed in the renal collecting tubules. Defects in AQP-2 are a cause of autosomal recessive nephrogenic diabetes insipidus (ANDI), also known as diabetes insipidus nephrogenic type 2. It is characterized by excessive water drinking (polydypsia) and urine excretion (polyuria). AQP-2 belongs to the MIP/aquaporin (TC1.A.8) family. Serine-269 has been identified as a vasopressin-mediated phosphorylation site on AQP2 and as such has shown to potentiate plasma membrane retention of AQP2.
Alternate Names: Aquaporin-2, AQP2, Aquaporin protein-2, AQP-2, Aquaporin-CD, AQP-CD, Water channel protein for renal collecting duct, ADH water channel, Collecting duct water channel protein, WCH-CD
Application Notes: E: 1:1,000; WB: 1:1,000
Accession No.: P34080
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser264 of human AQP2.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Metabolic Disorders
Description:
Aquaporin-2 (AQP-2) forms a water specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. It is expressed in the renal collecting tubules. Defects in AQP-2 are a cause of autosomal recessive nephrogenic diabetes insipidus (ANDI), also known as diabetes insipidus nephrogenic type 2. It is characterized by excessive water drinking (polydypsia) and urine excretion (polyuria). AQP-2 belongs to the MIP/aquaporin (TC1.A.8) family. Serine-269 has been identified as a vasopressin-mediated phosphorylation site on AQP2 and as such has shown to potentiate plasma membrane retention of AQP2.
Alternate Names: Aquaporin-2, AQP2, Aquaporin protein-2, AQP-2, Aquaporin-CD, AQP-CD, Water channel protein for renal collecting duct, ADH water channel, Collecting duct water channel protein, WCH-CD
Application Notes: E: 1:1,000; WB: 1:1,000
Accession No.: P34080
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser264 of human AQP2.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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