AR-β2 (phospho-S346) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4652
Background:
Beta 2 Adrenergic Receptor is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.
Alternative Name:
ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR, Beta-2 adrenergic receptor, ARβ2
Application Dilution: WB: 1:500~1:1000
Specificity: p-AR-β2 (S346) polyclonal antibody detects endogenous levels of AR-β2 protein only when phosphorylated at Ser346.
Immunogen:
Synthetic phosphopeptide derived from human AR-β2 around the phosphorylation site of Serine 346.
MW: ~ 47 kDa, 68 kDa (glycosylated), 95 kDa (Dimer)
Swis Prot.: P07550
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Beta 2 Adrenergic Receptor is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.
Alternative Name:
ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR, Beta-2 adrenergic receptor, ARβ2
Application Dilution: WB: 1:500~1:1000
Specificity: p-AR-β2 (S346) polyclonal antibody detects endogenous levels of AR-β2 protein only when phosphorylated at Ser346.
Immunogen:
Synthetic phosphopeptide derived from human AR-β2 around the phosphorylation site of Serine 346.
MW: ~ 47 kDa, 68 kDa (glycosylated), 95 kDa (Dimer)
Swis Prot.: P07550
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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