AREG polyclonal, anti-mouse, rat
€388.00
In stock
SKU
BS7305
Background:
Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs.
Alternative Name:
A REG, Amphiregulin, AR, AR, AREG, AREG_HUMAN, AREGB, Colorectum cell derived growth factor, Colorectum cell derived growth factor, Colorectum cell-derived growth factor, CRDGF, CRDGF, MGC13647, Schwannoma derived growth factor, SDGF,
Application Dilution: WB: 1:1000 - 1:2000
Specificity: AREG polyclonal antibody detects endogenous levels of AREG protein.
Immunogen:
Recombinant full length Human AREG.
MW: ~28 kDa
Swis Prot.: P15514
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs.
Alternative Name:
A REG, Amphiregulin, AR, AR, AREG, AREG_HUMAN, AREGB, Colorectum cell derived growth factor, Colorectum cell derived growth factor, Colorectum cell-derived growth factor, CRDGF, CRDGF, MGC13647, Schwannoma derived growth factor, SDGF,
Application Dilution: WB: 1:1000 - 1:2000
Specificity: AREG polyclonal antibody detects endogenous levels of AREG protein.
Immunogen:
Recombinant full length Human AREG.
MW: ~28 kDa
Swis Prot.: P15514
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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