ARFGAP3 Antibody (N-term) Blocking Peptide
€293.00
In stock
SKU
AC-BP2303a
Background:
ARFGAP3 is an GTPase-activating protein (GAP) probably for ARF1. This protein may be involved in protein secretion and/or vesicle transport. It likely participates in promoting hydrolysis of the ARF1-bound GTP and thus, may be required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Like other ARFGAPs, its activity is sensitive to phospholipids. Location is cytoplasmic, concentrated in the perinuclear region. Highest expression occurs in the endocrine glands (pancreas, pituary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary. ARFGAP3 is expressed at higher level in adult thymus, brain and lung, than in corresponding fetal tissues. It is expressed at lower level in spleen, heart, kidney and liver during development.
Other Names: ADP-ribosylation factor GTPase-activating protein 3, ARF GAP 3, ARFGAP3, ARFGAP1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2303a was selected from the N-term region of human ARFGAP3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q9NP61
Other Accession: NP_055385
Gene ID: 26286
Gene Name: ARFGAP3
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Zhang, C., et al., Genomics 63(3):400-408 (2000).Dunham, I., et al., Nature 402(6761):489-495 (1999).
ARFGAP3 is an GTPase-activating protein (GAP) probably for ARF1. This protein may be involved in protein secretion and/or vesicle transport. It likely participates in promoting hydrolysis of the ARF1-bound GTP and thus, may be required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Like other ARFGAPs, its activity is sensitive to phospholipids. Location is cytoplasmic, concentrated in the perinuclear region. Highest expression occurs in the endocrine glands (pancreas, pituary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary. ARFGAP3 is expressed at higher level in adult thymus, brain and lung, than in corresponding fetal tissues. It is expressed at lower level in spleen, heart, kidney and liver during development.
Other Names: ADP-ribosylation factor GTPase-activating protein 3, ARF GAP 3, ARFGAP3, ARFGAP1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2303a was selected from the N-term region of human ARFGAP3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q9NP61
Other Accession: NP_055385
Gene ID: 26286
Gene Name: ARFGAP3
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Zhang, C., et al., Genomics 63(3):400-408 (2000).Dunham, I., et al., Nature 402(6761):489-495 (1999).
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