ARHGAP18 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes, GTP-binding Proteins

Pathway and Disease: Membrane Transport, Signaling Molecules and Interaction

Description:
ARHGAP18 is one member of the human RhoGAP family with approximately 80 RhoGAP proteins known to be encoded in the human genome. Rho proteins belong to the Ras superfamily that is composed of over 50 members divided into six families, including Ras, Sar, Rho, Ran, Rab and Arf. Rho GTPases are important regulators of the actin cytoskeleton and consequently influence the shape and migration of cells. ARHGAP18 is linked to Ras, and thus, to EGFR-mediated proliferation, migration and differentiation. ARHGAP18 is precisely contained within chromosome 6q22-24, which has been shown to be linked to schizophrenia, suggesting that ARHGEP18 may play a role in this condition.

Alternate Names: ARHGAP18, Rho GTPase-activating protein 18, MacGAP, Rho-type GTPase-activating protein 18

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500; IF: 1:50-1:200

Accession No.: NP_277050

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ARHGAP18.

Format: Each vial contains 0.1 mg IgG (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.