ARHGEF3 Antibody (Center) Blocking peptide
€293.00
In stock
SKU
AC-BP5820c
Background:
Rho-like GTPases are involved in a variety of cellularprocesses, and they are activated by binding GTP and inactivated byconversion of GTP to GDP by their intrinsic GTPase activity.Guanine nucleotide exchange factors (GEFs) accelerate the GTPaseactivity of Rho GTPases by catalyzing their release of bound GDP.This gene encodes a guanine nucleotide exchange factor, whichspecifically activates two members of the Rho GTPase family: RHOAand RHOB, both of which have a role in bone cell biology. It hasbeen identified that genetic variation in this gene plays a role inthe determination of bone mineral density (BMD), indicating theimplication of this gene in postmenopausal osteoporosis.Alternatively spliced transcript variants encoding differentisoforms have been found for this gene.
Other Names: Rho guanine nucleotide exchange factor 3, Exchange factor found in platelets and leukemic and neuronal tissues, XPLN, ARHGEF3
Type: Synthetic peptide
Primary Accession: Q9NR81
Other Accession: NP_062455.1
Gene ID: 50650
Gene Name: ARHGEF3
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Arthur, W.T., et al. J. Biol. Chem. 277(45):42964-42972(2002)Harrington, A.W., et al. J. Neurosci. 22(1):156-166(2002)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)Thiesen, S., et al. Biochem. Biophys. Res. Commun. 273(1):364-369(2000)
Rho-like GTPases are involved in a variety of cellularprocesses, and they are activated by binding GTP and inactivated byconversion of GTP to GDP by their intrinsic GTPase activity.Guanine nucleotide exchange factors (GEFs) accelerate the GTPaseactivity of Rho GTPases by catalyzing their release of bound GDP.This gene encodes a guanine nucleotide exchange factor, whichspecifically activates two members of the Rho GTPase family: RHOAand RHOB, both of which have a role in bone cell biology. It hasbeen identified that genetic variation in this gene plays a role inthe determination of bone mineral density (BMD), indicating theimplication of this gene in postmenopausal osteoporosis.Alternatively spliced transcript variants encoding differentisoforms have been found for this gene.
Other Names: Rho guanine nucleotide exchange factor 3, Exchange factor found in platelets and leukemic and neuronal tissues, XPLN, ARHGEF3
Type: Synthetic peptide
Primary Accession: Q9NR81
Other Accession: NP_062455.1
Gene ID: 50650
Gene Name: ARHGEF3
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Arthur, W.T., et al. J. Biol. Chem. 277(45):42964-42972(2002)Harrington, A.W., et al. J. Neurosci. 22(1):156-166(2002)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)Thiesen, S., et al. Biochem. Biophys. Res. Commun. 273(1):364-369(2000)
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