ARK5 Antibody (N-term) Blocking Peptide
€293.00
In stock
SKU
AC-BP8066a
Background:
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
Other Names: NUAK family SNF1-like kinase 1, AMPK-related protein kinase 5, ARK5, Omphalocele kinase 1, NUAK1, ARK5, KIAA0537, OMPHK1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8066a was selected from the N-term region of human ARK5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: O60285
Gene ID: 9891
Gene Name: NUAK1
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Suzuki, A., et al., Mol. Cell. Biol. 24(8):3526-3535 (2004).Suzuki, A., et al., Oncogene 22(40):6177-6182 (2003).Suzuki, A., et al., J. Biol. Chem. 278(1):48-53 (2003).
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
Other Names: NUAK family SNF1-like kinase 1, AMPK-related protein kinase 5, ARK5, Omphalocele kinase 1, NUAK1, ARK5, KIAA0537, OMPHK1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8066a was selected from the N-term region of human ARK5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: O60285
Gene ID: 9891
Gene Name: NUAK1
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Suzuki, A., et al., Mol. Cell. Biol. 24(8):3526-3535 (2004).Suzuki, A., et al., Oncogene 22(40):6177-6182 (2003).Suzuki, A., et al., J. Biol. Chem. 278(1):48-53 (2003).
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