ARRB1 Polyclonal Antibody

Background:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

Research Area: Cancer, Neuroscience, Signal Transduction

Synonyms:
ARB1, ARR1, ARRB1, ARRB1, Arrestin 2, Arrestin beta 1, Arrestin beta-1, Beta-arrestin-1

Immunogen: Recombinant protein of human ARRB1

Swissprot: P49407
Gene Accession: BC003636

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-9182/sc-6388/sc-6389/sc-28869