Arrestin-β-1 (clone ), anti-human, mouse, rat
€388.00
In stock
SKU
MB0001
Background:
Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane.
Alternative Name:
ARB 1, ARB1, ARR 1, ARR1, ARRB 1, ARRB1, Arrestin 2, Arrestin beta 1, Arrestin beta-1, Beta-arrestin-1, Arrestin-β1, Arrestin β1, β-arrestin-1
Application Dilution: WB: 1:500~1000
Specificity: This antibody detects endogenous levels of Arrestin-β-1 and does not cross-react with related proteins.
Immunogen:
Recombinant full length Human Arrestin-β-1.
MW: Predicted band size: 50kDa, Observed band size: 50kDa
Swis Prot.: P49407
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane.
Alternative Name:
ARB 1, ARB1, ARR 1, ARR1, ARRB 1, ARRB1, Arrestin 2, Arrestin beta 1, Arrestin beta-1, Beta-arrestin-1, Arrestin-β1, Arrestin β1, β-arrestin-1
Application Dilution: WB: 1:500~1000
Specificity: This antibody detects endogenous levels of Arrestin-β-1 and does not cross-react with related proteins.
Immunogen:
Recombinant full length Human Arrestin-β-1.
MW: Predicted band size: 50kDa, Observed band size: 50kDa
Swis Prot.: P49407
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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