ARSB polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60835
Background:
Arylsulfatase B, also known as ARSB, ASB, MPS6 or G4S, is a 533 amino acid lysosomal protein that belongs to the sulfatase family. Existing as both a monomer and a homodimer, Arylsulfatase B uses calcium as a cofactor to hydrolyze C4-sulfate groups of N-Acetyl-D-galactosamine, dermatan sulfate and chondriotin sulfate, thereby playing a role in lysosomal degradation. Defects in the gene encoding Arylsulfatase B are the cause of mucopolysaccharidosis type 6 (MPS6) and multiple sulfatase deficiency (MSD), the first of which is a lysosomal storage disease that is characterized by short stature, stiff joints, skeletal malformations, corneal clouding, hepatosplenomegaly and cardiac abnormalities. In contrast, MSD is characterized by a decreased activity of all known sulfatases and is usually associated with mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis and neurologic deterioration. Multiple isoforms of Arylsulfatase B exist due to alternative splicing events.
Alternative Name:
Arylsulfatase B, ASB, N-acetylgalactosamine-4-sulfatase, G4S, ARSB
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ARSB polyclonal antibody detects endogenous levels of ARSB protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ARSB.
MW: ~ 46 kDa
Swis Prot.: P15848
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 101% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.9.
Storage:
Store at 4°C short term. Aliquot and store at -26°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Arylsulfatase B, also known as ARSB, ASB, MPS6 or G4S, is a 533 amino acid lysosomal protein that belongs to the sulfatase family. Existing as both a monomer and a homodimer, Arylsulfatase B uses calcium as a cofactor to hydrolyze C4-sulfate groups of N-Acetyl-D-galactosamine, dermatan sulfate and chondriotin sulfate, thereby playing a role in lysosomal degradation. Defects in the gene encoding Arylsulfatase B are the cause of mucopolysaccharidosis type 6 (MPS6) and multiple sulfatase deficiency (MSD), the first of which is a lysosomal storage disease that is characterized by short stature, stiff joints, skeletal malformations, corneal clouding, hepatosplenomegaly and cardiac abnormalities. In contrast, MSD is characterized by a decreased activity of all known sulfatases and is usually associated with mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis and neurologic deterioration. Multiple isoforms of Arylsulfatase B exist due to alternative splicing events.
Alternative Name:
Arylsulfatase B, ASB, N-acetylgalactosamine-4-sulfatase, G4S, ARSB
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ARSB polyclonal antibody detects endogenous levels of ARSB protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ARSB.
MW: ~ 46 kDa
Swis Prot.: P15848
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 101% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.9.
Storage:
Store at 4°C short term. Aliquot and store at -26°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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