Artemis (phospho Ser516) polyclonal, anti-human, mouse

Background:
This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by non homologous end joining.

Synonyms: SCIDA, SNM1C, A-SCID, RS-SCID, DCLREC1C

Cellular Location: Nucleus

Immunogen:
A synthetic peptide of human Artemis (phospho Ser516)

Gene Symbol: Artemis (phospho Ser516)

Gene ID: 64421

Swiss prot: Q96SD1

Calculated MW: 78kDa

Recommended dilution:
WB 1:500-2000, IHC 1:100-300,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.