ASAH1 polyclonal, anti-human, mouse, rat
€414.00
In stock
SKU
253920
Catalog Nr.: 253920
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IF
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IF
Protein Family: Enzymes, Peptidases
Pathway and Disease: Lipid Metabolism, Membrane Transport, Signal Transduction
Description:
Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulminary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer’s disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombinant AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. Multiple isoforms of this protein are known to exist.
Alternate Names: ASAH1, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 1, acid ceramidase, ACDase, Acid Cdase, acylsphingosine deacylase, putative 32 kDa heart protein, PHP32, ASAH, HSD-33, HSD33
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IF: 1:50-1:200
Accession No.: EAW63795
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ASAH1.
Format: Each vial contains 0.1 ml IgG (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Lipid Metabolism, Membrane Transport, Signal Transduction
Description:
Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulminary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer’s disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombinant AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. Multiple isoforms of this protein are known to exist.
Alternate Names: ASAH1, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 1, acid ceramidase, ACDase, Acid Cdase, acylsphingosine deacylase, putative 32 kDa heart protein, PHP32, ASAH, HSD-33, HSD33
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IF: 1:50-1:200
Accession No.: EAW63795
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ASAH1.
Format: Each vial contains 0.1 ml IgG (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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