Ascomycin
€0.00
In stock
SKU
BW-40110044
Synonyms: Immunomycin, FK520, FR-900520
Ascomycin is a macrolide immunosuppressant antibiotic. It is an ethyl analog of FK506. Ascomycin binds to the FK-506-binding protein FKBP12 and blocks the peptidyl-prolyl cis-trans isomerase activity of the protein. This bound complex inhibits calcineurin phosphatase in the nM range, consequently suppressing the presentation of Th1 and Th2-type cytokines in cells and reducing production of interleukins IL-2, 4, and 10, leading to immunosuppression. Pimecrolimus, an Ascomycin derivative, has been shown to block the release of allergic response mediators from mast cells.
Warning: For laboratory use only. Not fit for agricultural, household, clinical use or human consumption.
Technical Specifications:
Density:1.19 g/cm3
Melting Point:153-157°C
Boiling Point:868.3°C at 760 mmHg
Flash Point:478.9°C
Solubility: Soluble in methanol, ethanol, acetone, ethyl acetate, chloroform; slightly soluble in n-hexane and petroleum ether; insoluble in water
Molecular Weight: 792.01
Molecular Formula: C43H69NO12
Purity: >95%
Hazmat Shipping: Non-hazardous
Storage: -20°C
Solubility: Methanol: 10 mg/mL
Solubility Color : Clear to slightly hazy, colorless to light yellow
Appearance Form: Powder
Appearance Color: White to yellow
Melting Point: 153 - 157°C
Brand Name: bioPLUS™
Ascomycin is a macrolide immunosuppressant antibiotic. It is an ethyl analog of FK506. Ascomycin binds to the FK-506-binding protein FKBP12 and blocks the peptidyl-prolyl cis-trans isomerase activity of the protein. This bound complex inhibits calcineurin phosphatase in the nM range, consequently suppressing the presentation of Th1 and Th2-type cytokines in cells and reducing production of interleukins IL-2, 4, and 10, leading to immunosuppression. Pimecrolimus, an Ascomycin derivative, has been shown to block the release of allergic response mediators from mast cells.
Warning: For laboratory use only. Not fit for agricultural, household, clinical use or human consumption.
Technical Specifications:
Density:1.19 g/cm3
Melting Point:153-157°C
Boiling Point:868.3°C at 760 mmHg
Flash Point:478.9°C
Solubility: Soluble in methanol, ethanol, acetone, ethyl acetate, chloroform; slightly soluble in n-hexane and petroleum ether; insoluble in water
Molecular Weight: 792.01
Molecular Formula: C43H69NO12
Purity: >95%
Hazmat Shipping: Non-hazardous
Storage: -20°C
Solubility: Methanol: 10 mg/mL
Solubility Color : Clear to slightly hazy, colorless to light yellow
Appearance Form: Powder
Appearance Color: White to yellow
Melting Point: 153 - 157°C
Brand Name: bioPLUS™
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