ASPP2 polyclonal, anti-human, mouse, rat
€378.00
In stock
SKU
251646
Catalog Nr.: 251646
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Transcription Factors
Pathway and Disease: Signaling Molecules and Interaction, Cell Growth and Death
Description:
Apoptosis-stimulating of p53 protein 2 (ASPP2) is a regulator that plays a central role in regulation of apoptosis and cell growth. ASPP2 regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. ASPP2 inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. ASPP2 impedes cell cycle progression at G2/M. The apoptosis-stimulating activity of ASPP2 is inhibited by its interaction with DDX42.
Alternate Names: ASPP2, Apoptosis-stimulating of p53 protein 2, Tumor suppressor p53-binding protein 2, p53-binding protein 2, p53BP2, 53BP2, Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51, TP53BP2, BBP
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: Q13625
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ASPP2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Xiangrong L et al. 2013. American Heart Association Journals. Stroke. 2013.44:1973-1980. PMID# 2369548.
Pathway and Disease: Signaling Molecules and Interaction, Cell Growth and Death
Description:
Apoptosis-stimulating of p53 protein 2 (ASPP2) is a regulator that plays a central role in regulation of apoptosis and cell growth. ASPP2 regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. ASPP2 inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. ASPP2 impedes cell cycle progression at G2/M. The apoptosis-stimulating activity of ASPP2 is inhibited by its interaction with DDX42.
Alternate Names: ASPP2, Apoptosis-stimulating of p53 protein 2, Tumor suppressor p53-binding protein 2, p53-binding protein 2, p53BP2, 53BP2, Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51, TP53BP2, BBP
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: Q13625
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ASPP2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Xiangrong L et al. 2013. American Heart Association Journals. Stroke. 2013.44:1973-1980. PMID# 2369548.
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