Ataxin-1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7968
Background:
Ataxin-1, also designated spinocerebellar ataxia type 1 protein (Sca-1), is differentially expressed and localizes to both the cytoplasm and the nucleus. Mutations in Ataxin-1 are associated with the onset of the autosomal dominant neurodegenerative disorder spinocerebellar ataxia type 1 (SCA-1), which is characterized by progressive neuronal loss in the cerebellum, muscle wasting and ataxia. In Purkinje cells, where SCA-1 is predominantly observed, Ataxin-1 has been shown to directly associate with the Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and the nuclear matrix-associated protein promyelocytic leukemia protein PML. In SCA-1, Ataxin-1 is mutated to encode a polyglutamine protein that forms nuclear aggregates, which interact significantly more strongly with LANP and contribute to the pathogenesis of SCA-1.
Alternative Name:
alternative ataxin1, Ataxin-1, ATX1, ATX1_HUMAN, Atxn1, D6S504E, SCA1, Spinocerebellar ataxia type 1 protein,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: Ataxin-1 polyclonal antibody detects endogenous levels of Ataxin-1 protein.
Immunogen:
Recombinant full length Human Ataxin-1.
MW: ~ 84 kDa
Swis Prot.: P54253
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Ataxin-1, also designated spinocerebellar ataxia type 1 protein (Sca-1), is differentially expressed and localizes to both the cytoplasm and the nucleus. Mutations in Ataxin-1 are associated with the onset of the autosomal dominant neurodegenerative disorder spinocerebellar ataxia type 1 (SCA-1), which is characterized by progressive neuronal loss in the cerebellum, muscle wasting and ataxia. In Purkinje cells, where SCA-1 is predominantly observed, Ataxin-1 has been shown to directly associate with the Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and the nuclear matrix-associated protein promyelocytic leukemia protein PML. In SCA-1, Ataxin-1 is mutated to encode a polyglutamine protein that forms nuclear aggregates, which interact significantly more strongly with LANP and contribute to the pathogenesis of SCA-1.
Alternative Name:
alternative ataxin1, Ataxin-1, ATX1, ATX1_HUMAN, Atxn1, D6S504E, SCA1, Spinocerebellar ataxia type 1 protein,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: Ataxin-1 polyclonal antibody detects endogenous levels of Ataxin-1 protein.
Immunogen:
Recombinant full length Human Ataxin-1.
MW: ~ 84 kDa
Swis Prot.: P54253
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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