ATF-3 polyclonal, anti-human, mouse, rat

Protein Family: Transcription Factors

Pathway and Disease: Transcription

Description:
Cyclic AMP-dependent transcription factor ATF-3 (ATF-3) is a protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. ATF-3 represses transcription from promoters with ATF sites. ATF-3 represses transcription by stabilizing the binding of inhibitory cofactors at the promoter. ATF-3 isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

Alternate Names: ATF-3, Activating Transcription Factor 3, ATF3, Cyclic AMP-dependent transcription factor ATF-3, cAMP-dependent transcription factor ATF-3, Activating transcription factor 3

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P18847

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ATF-3.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.