ATF2 (Ser490/498) polyclonal, anti-human, rat
€440.00
In stock
SKU
252524
Catalog Nr.: 252524
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Transcription Factors
Pathway and Disease: Signal Transduction, Transcription
Description:
Activating transcription factor 2 (ATF2) is a transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) consensus sequence: 5'-GTGACGT[AC][AG]-3', a sequence present in many viral and cellular promoters. ATF2 binds DNA as a dimer and can form a homodimer in the absence of DNA. ATF2 can form a heterodimer with JUN, and interacts with SMAD3 and SMAD4. Stress induced ATF-dependent transcription is dependent on phosphorylation of ATF.
Alternate Names: ATF-2, Activating Transcription Factor 2, ATF2, Cyclic AMP-dependent transcription factor ATF-2, cAMP-dependent transcription factor ATF-2, Activating transcription factor 2, cAMP response element-binding protein CRE-BP1, HB16, Cyclic AMP-responsive element-binding protein 2, cAMP-responsive element-binding protein 2, CREB-2, CREB2, CREBP1
Application Notes: E: 1:1,000; WB: 1:1,000; IHC: 1:1,000
Accession No.: P15336
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser490/498 of rat ATF2.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signal Transduction, Transcription
Description:
Activating transcription factor 2 (ATF2) is a transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) consensus sequence: 5'-GTGACGT[AC][AG]-3', a sequence present in many viral and cellular promoters. ATF2 binds DNA as a dimer and can form a homodimer in the absence of DNA. ATF2 can form a heterodimer with JUN, and interacts with SMAD3 and SMAD4. Stress induced ATF-dependent transcription is dependent on phosphorylation of ATF.
Alternate Names: ATF-2, Activating Transcription Factor 2, ATF2, Cyclic AMP-dependent transcription factor ATF-2, cAMP-dependent transcription factor ATF-2, Activating transcription factor 2, cAMP response element-binding protein CRE-BP1, HB16, Cyclic AMP-responsive element-binding protein 2, cAMP-responsive element-binding protein 2, CREB-2, CREB2, CREBP1
Application Notes: E: 1:1,000; WB: 1:1,000; IHC: 1:1,000
Accession No.: P15336
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser490/498 of rat ATF2.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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