ATG2A polyclonal, anti-human
€388.00
In stock
SKU
BS71850
Background:
Atg2A (TG2 autophagy related 2 homolog A) is a 1,938 amino acid protein that belongs to the ATG2 family and may play a role in vesicle assembly. Encoded by a gene that maps to human chromosome 11q13.1, Atg2A is conserved in chimpanzee, dog, cow, mouse and rat, and exists as four alternatively spliced isoforms. Undetected in adult tissues, including heart, brain, placenta, lung, liver and skeletal muscle, Atg2A regulation may act as a distinct indicator of autophagic programmed cell death. Atg2A is upregulated in both etoposide- and doxorubicin-induced apoptosis of HeLa cells, suggesting that Atg2A functions as a novel biomarker of topoisomerase II inhibitor-mediated apoptosis. Atg2A associates with Atg2B, indicating that these two related proteins also functionally interact. Atg2A frameshift mutations are linked to gastric and colorectal carcinomas with high microsatellite instability and may contribute to cancer development by deregulating the autophagy process.
Alternative Name:
Autophagy-related protein 2 homolog A, KIAA0404
Application Dilution: WB: 1:500 - 1:2000
Specificity: ATG2A polyclonal antibody detects endogenous levels of ATG2A protein.
Immunogen:
A synthetic peptide of human ATG2A
MW: 213kDa
Swis Prot.: Q2TAZ0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Atg2A (TG2 autophagy related 2 homolog A) is a 1,938 amino acid protein that belongs to the ATG2 family and may play a role in vesicle assembly. Encoded by a gene that maps to human chromosome 11q13.1, Atg2A is conserved in chimpanzee, dog, cow, mouse and rat, and exists as four alternatively spliced isoforms. Undetected in adult tissues, including heart, brain, placenta, lung, liver and skeletal muscle, Atg2A regulation may act as a distinct indicator of autophagic programmed cell death. Atg2A is upregulated in both etoposide- and doxorubicin-induced apoptosis of HeLa cells, suggesting that Atg2A functions as a novel biomarker of topoisomerase II inhibitor-mediated apoptosis. Atg2A associates with Atg2B, indicating that these two related proteins also functionally interact. Atg2A frameshift mutations are linked to gastric and colorectal carcinomas with high microsatellite instability and may contribute to cancer development by deregulating the autophagy process.
Alternative Name:
Autophagy-related protein 2 homolog A, KIAA0404
Application Dilution: WB: 1:500 - 1:2000
Specificity: ATG2A polyclonal antibody detects endogenous levels of ATG2A protein.
Immunogen:
A synthetic peptide of human ATG2A
MW: 213kDa
Swis Prot.: Q2TAZ0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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