ATIC (clone ), anti-human, mouse, rat
€388.00
In stock
SKU
MB0029
Background:
The bifunctional purine biosynthesis protein ATIC (also designated PURH) contains AICAR transformylase and IMP cyclohydrolase activities. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase catalyzes the second to last step in purine biosynthesis, playing an important role in the production of nucleotides and IMP. Defects in the ATIC transformylase gene can cause AICA-rebsuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-riboside, also designated ZMP, and its derivatives in erythrocytes and fibroblasts. Patients also excrete very large amounts of AICA-riboside in the urine.
Alternative Name:
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR transformylase2.IMP cyclohydrolase, ATIC, IMP synthase Inosinicase, PURH, AICAR, AICARFT, IMPCHASE
Application Dilution: WB: 1:1000
Specificity: This antibody detects endogenous levels of ATIC and does not cross-react with related proteins
Immunogen:
Recombinant full length Human ATIC.
MW: Predicted band size: 64KDa , Observed band size: 64KDa
Swis Prot.: P31939
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The bifunctional purine biosynthesis protein ATIC (also designated PURH) contains AICAR transformylase and IMP cyclohydrolase activities. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase catalyzes the second to last step in purine biosynthesis, playing an important role in the production of nucleotides and IMP. Defects in the ATIC transformylase gene can cause AICA-rebsuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-riboside, also designated ZMP, and its derivatives in erythrocytes and fibroblasts. Patients also excrete very large amounts of AICA-riboside in the urine.
Alternative Name:
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR transformylase2.IMP cyclohydrolase, ATIC, IMP synthase Inosinicase, PURH, AICAR, AICARFT, IMPCHASE
Application Dilution: WB: 1:1000
Specificity: This antibody detects endogenous levels of ATIC and does not cross-react with related proteins
Immunogen:
Recombinant full length Human ATIC.
MW: Predicted band size: 64KDa , Observed band size: 64KDa
Swis Prot.: P31939
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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