ATIC polyclonal, anti-human
€388.00
In stock
SKU
BS6973
Background:
The bifunctional purine biosynthesis protein ATIC (also designated PURH) contains AICAR transformylase and IMP cyclohydrolase activities. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase catalyzes the second to last step in purine biosynthesis, playing an important role in the production of nucleotides and IMP. Defects in the ATIC transformylase gene can cause AICA-rebsuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic.
Alternative Name:
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR transformylase2.IMP cyclohydrolase, ATIC, IMP synthase Inosinicase, PURH, AICAR, AICARFT, IMPCHASE
Application Dilution: WB: 1:500 - 1:2000
Specificity: ATIC polyclonal antibody detects endogenous levels of ATICprotein.
Immunogen:
Recombinant full length Human ATIC.
MW: ~ 64 kDa
Swis Prot.: P31939
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The bifunctional purine biosynthesis protein ATIC (also designated PURH) contains AICAR transformylase and IMP cyclohydrolase activities. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase catalyzes the second to last step in purine biosynthesis, playing an important role in the production of nucleotides and IMP. Defects in the ATIC transformylase gene can cause AICA-rebsuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic.
Alternative Name:
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR transformylase2.IMP cyclohydrolase, ATIC, IMP synthase Inosinicase, PURH, AICAR, AICARFT, IMPCHASE
Application Dilution: WB: 1:500 - 1:2000
Specificity: ATIC polyclonal antibody detects endogenous levels of ATICprotein.
Immunogen:
Recombinant full length Human ATIC.
MW: ~ 64 kDa
Swis Prot.: P31939
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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