ATM (clone ), anti-human
€428.00
In stock
SKU
BS9893M
Background:
The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.
Alternative Name:
Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated, ATM
Application Dilution: WB: 1:1000-1:5000, ICC/IF: 1:50-1:200, IHC: 1:50-1:200
Specificity: This antibody detects endogenous levels of ATM and does not cross-react with related proteins.
Immunogen:
Recombinant antibody.
MW: ~ 370 kDa
Swis Prot.: Q13315
Purification & Purity:
Protein A affinity purified
Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.
Alternative Name:
Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated, ATM
Application Dilution: WB: 1:1000-1:5000, ICC/IF: 1:50-1:200, IHC: 1:50-1:200
Specificity: This antibody detects endogenous levels of ATM and does not cross-react with related proteins.
Immunogen:
Recombinant antibody.
MW: ~ 370 kDa
Swis Prot.: Q13315
Purification & Purity:
Protein A affinity purified
Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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