ATM (I1987) polyclonal, anti-human
€305.00
In stock
SKU
BS5505
Background:
The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.
Alternative Name:
A-T mutated, A-T mutated homolog, AT complementation group A, AT complementation group C, AT complementation group D, AT complementation group E, AT mutated, AT protein, AT1, AT1, ATA, Ataxia telangiectasia gene mutated in human beings, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated gene, Ataxia telangiectasia mutated homolog (human), Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, ATM, ATM, DKFZp781A0353, Human phosphatidylinositol 3 kinase homolog, MGC74674, OTT
Application Dilution: IHC: 1:50~1:200
Specificity: ATM (I1987) polyclonal antibody detects endogenous levels of ATM protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 1957-2006 of Human ATM.
MW: ~ 350 kDa
Swis Prot.: Q13315
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.
Alternative Name:
A-T mutated, A-T mutated homolog, AT complementation group A, AT complementation group C, AT complementation group D, AT complementation group E, AT mutated, AT protein, AT1, AT1, ATA, Ataxia telangiectasia gene mutated in human beings, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated gene, Ataxia telangiectasia mutated homolog (human), Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, ATM, ATM, DKFZp781A0353, Human phosphatidylinositol 3 kinase homolog, MGC74674, OTT
Application Dilution: IHC: 1:50~1:200
Specificity: ATM (I1987) polyclonal antibody detects endogenous levels of ATM protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 1957-2006 of Human ATM.
MW: ~ 350 kDa
Swis Prot.: Q13315
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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