Atm (phospho Ser1981) Polyclonal Antibody

Background:
ATM serine/threonine kinase(ATM) Homo sapiens The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],

Alternative Names:
ATM, Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Atm (phospho Ser1981)

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 350

GeneID: ATM

Storage: -20°C/1 year

NOTE: For Research Use Only