ATRX Antibody (C-term) Blocking Peptide
€293.00
In stock
SKU
AC-BP2541c
Background:
ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. Theses mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis.
Other Names: Transcriptional regulator ATRX, ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein, XNP, Znf-HX, ATRX, RAD54L, XH2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2541c was selected from the C-term region of human ATRX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: P46100
Gene ID: 546
Gene Name: ATRX
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Mazina, O.M., et al., J. Biol. Chem. 279(50):52042-52051 (2004).Tang, P., et al., Trends Endocrinol. Metab. 15(7):339-344 (2004).Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004).Steensma, D.P., et al., Blood 103(6):2019-2026 (2004).Tang, J., et al., J. Biol. Chem. 279(19):20369-20377 (2004).
ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. Theses mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis.
Other Names: Transcriptional regulator ATRX, ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein, XNP, Znf-HX, ATRX, RAD54L, XH2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2541c was selected from the C-term region of human ATRX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: P46100
Gene ID: 546
Gene Name: ATRX
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Mazina, O.M., et al., J. Biol. Chem. 279(50):52042-52051 (2004).Tang, P., et al., Trends Endocrinol. Metab. 15(7):339-344 (2004).Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004).Steensma, D.P., et al., Blood 103(6):2019-2026 (2004).Tang, J., et al., J. Biol. Chem. 279(19):20369-20377 (2004).
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