AURKB (clone 13E8D3), anti-human
€443.00
In stock
SKU
252689
Catalog Nr.: 252689
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Cell Growth and Death
Description:
Aurora B is involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Aurora B is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Aurora B phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis, and is required for kinetochore localization of BUB1 and SGOL1.
Alternate Names: Serine/threonine-protein kinase 12, Aurora kinase B, Serine/threonine-protein kinase aurora-B, Aurora- and IPL1-like midbody-associated protein 1, AIM-1, Aurora/IPL1-related kinase 2, Aurora-related kinase 2, ARK-2, STK-1, AURKB, AIK2, AIM1, ARK2, STK12
Application Notes: WB: 1:500-1:2000
Accession No.: Q96GD4
Antigen: Purified recombinant fragment of AURKB expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cell Growth and Death
Description:
Aurora B is involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Aurora B is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Aurora B phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis, and is required for kinetochore localization of BUB1 and SGOL1.
Alternate Names: Serine/threonine-protein kinase 12, Aurora kinase B, Serine/threonine-protein kinase aurora-B, Aurora- and IPL1-like midbody-associated protein 1, AIM-1, Aurora/IPL1-related kinase 2, Aurora-related kinase 2, ARK-2, STK-1, AURKB, AIK2, AIM1, ARK2, STK12
Application Notes: WB: 1:500-1:2000
Accession No.: Q96GD4
Antigen: Purified recombinant fragment of AURKB expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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