AXIN2 Blocking Peptide (C-term)
€293.00
In stock
SKU
AC-BP5416b
Background:
The Axin-related protein, Axin2, presumably plays an
important role in the regulation of the stability of beta-catenin
in the Wnt signaling pathway, like its rodent homologs, mouse
conductin/rat axil. In mouse, conductin organizes a multiprotein
complex of APC (adenomatous polyposis of the colon), beta-catenin,
glycogen synthase kinase 3-beta, and conductin, which leads to the
degradation of beta-catenin. Apparently, the deregulation of
beta-catenin is an important event in the genesis of a number of
malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region
that shows frequent loss of heterozygosity in breast cancer,
neuroblastoma, and other tumors. Mutations in this gene have been
associated with colorectal cancer with defective mismatch repair.
Other Names: Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin, AXIN2
Target/Specificity:
The synthetic peptide sequence is selected from aa 831-843 of HUMAN AXIN2
Type: Synthetic peptide
Primary Accession: Q9Y2T1
Other Accession: O70240; O88566; NP_004646.3
Gene ID: 8313
Gene Name: AXIN2
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Inkster, B., et al. Neuroimage (2010) In press :
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010)
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Olschwang, S., et al. J Oncol 2009, 306786 (2009) :
Dong, X., et al. Cytogenet. Cell Genet. 93 (1-2), 26-28 (2001) :
Liu, W., et al. Nat. Genet. 26(2):146-147(2000)
von Kries, J.P., et al. Nat. Struct. Biol. 7(9):800-807(2000)
Kikuchi, A. Cytokine Growth Factor Rev. 10 (3-4), 255-265 (1999) :
Mai, M., et al. Genomics 55(3):341-344(1999)
The Axin-related protein, Axin2, presumably plays an
important role in the regulation of the stability of beta-catenin
in the Wnt signaling pathway, like its rodent homologs, mouse
conductin/rat axil. In mouse, conductin organizes a multiprotein
complex of APC (adenomatous polyposis of the colon), beta-catenin,
glycogen synthase kinase 3-beta, and conductin, which leads to the
degradation of beta-catenin. Apparently, the deregulation of
beta-catenin is an important event in the genesis of a number of
malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region
that shows frequent loss of heterozygosity in breast cancer,
neuroblastoma, and other tumors. Mutations in this gene have been
associated with colorectal cancer with defective mismatch repair.
Other Names: Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin, AXIN2
Target/Specificity:
The synthetic peptide sequence is selected from aa 831-843 of HUMAN AXIN2
Type: Synthetic peptide
Primary Accession: Q9Y2T1
Other Accession: O70240; O88566; NP_004646.3
Gene ID: 8313
Gene Name: AXIN2
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Inkster, B., et al. Neuroimage (2010) In press :
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010)
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Olschwang, S., et al. J Oncol 2009, 306786 (2009) :
Dong, X., et al. Cytogenet. Cell Genet. 93 (1-2), 26-28 (2001) :
Liu, W., et al. Nat. Genet. 26(2):146-147(2000)
von Kries, J.P., et al. Nat. Struct. Biol. 7(9):800-807(2000)
Kikuchi, A. Cytokine Growth Factor Rev. 10 (3-4), 255-265 (1999) :
Mai, M., et al. Genomics 55(3):341-344(1999)
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