B-RAF Antibody (T439) Blocking peptide
€293.00
In stock
SKU
AC-BP7810i
Background:
BRAF, a member of the RAF subfamily of Ser/Thr protein kinases, is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It may play a role in the postsynaptic responses of hippocampal neurons. This cytoplasmic protein is expressed in brain and testis. Defects in BRAF are involved in a wide range of cancers including lung cancer and non-Hodgkin lymphoma (NHL). This protein contains 1 zinc-dependent phorbol-ester and DAG binding domain.
Other Names: Serine/threonine-protein kinase B-raf, Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1, BRAF, BRAF1, RAFB1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7810i was selected from the T439 region of human BRAF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: P15056
Gene ID: 673
Gene Name: BRAF
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Hingorani, S.R., et al., Cancer Res. 63(17):5198-5202 (2003).Lee, J.W., et al., Br. J. Cancer 89(10):1958-1960 (2003).Davies, H., et al., Nature 417(6892):949-954 (2002).Naoki, K., et al., Cancer Res. 62(23):7001-7003 (2002).Stephens, R.M., et al., Mol. Cell. Biol. 12(9):3733-3742 (1992).
BRAF, a member of the RAF subfamily of Ser/Thr protein kinases, is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It may play a role in the postsynaptic responses of hippocampal neurons. This cytoplasmic protein is expressed in brain and testis. Defects in BRAF are involved in a wide range of cancers including lung cancer and non-Hodgkin lymphoma (NHL). This protein contains 1 zinc-dependent phorbol-ester and DAG binding domain.
Other Names: Serine/threonine-protein kinase B-raf, Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1, BRAF, BRAF1, RAFB1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7810i was selected from the T439 region of human BRAF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: P15056
Gene ID: 673
Gene Name: BRAF
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Hingorani, S.R., et al., Cancer Res. 63(17):5198-5202 (2003).Lee, J.W., et al., Br. J. Cancer 89(10):1958-1960 (2003).Davies, H., et al., Nature 417(6892):949-954 (2002).Naoki, K., et al., Cancer Res. 62(23):7001-7003 (2002).Stephens, R.M., et al., Mol. Cell. Biol. 12(9):3733-3742 (1992).
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