B3GALNT1 Blocking Peptide (N-term)

Background:
This gene is a member of the
beta-1,3-galactosyltransferase (beta3GalT) gene family. This family
encodes type II membrane-bound glycoproteins with diverse enzymatic
functions using different donor substrates (UDP-galactose and
UDP-N-acetylglucosamine) and different acceptor sugars
(N-acetylglucosamine, galactose, N-acetylgalactosamine). The
beta3GalT genes are distantly related to the Drosophila Brainiac
gene and have the protein coding sequence contained in a single
exon. The beta3GalT proteins also contain conserved sequences not
found in the beta4GalT or alpha3GalT proteins. The carbohydrate
chains synthesized by these enzymes are designated as type 1,
whereas beta4GalT enzymes synthesize type 2 carbohydrate chains.
The ratio of type 1:type 2 chains changes during embryogenesis. By
sequence similarity, the beta3GalT genes fall into at least two
groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3,
beta3GalT5). The encoded protein of this gene does not use
N-acetylglucosamine as an acceptor sugar at all. Multiple
transcript variants that are alternatively spliced in the 5' UTR
have been described; they all encode the same protein. [provided by
RefSeq].

Other Names: UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1, Beta-1,3-GalNAc-T1, Beta-1,3-galactosyltransferase 3, Beta-1,3-GalTase 3, Beta3Gal-T3, Beta3GalT3, b3Gal-T3, Beta-3-Gx-T3, Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase, Globoside synthase, UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase, B3GALNT1, B3GALT3

Target/Specificity:
The synthetic peptide sequence is selected from aa 53-64 of HUMAN B3GALNT1

Type: Synthetic peptide

Primary Accession: O75752

Other Accession: Q864U6; NP_001033717.1; NP_149358.1; NP_149357.1; NP_149359.1; NP_003772.1

Gene ID: 8706

Gene Name: B3GALNT1 (HGNC:918)

Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Bio References:
Masui, S., et al. Int. J. Legal Med. 123(3):205-211(2009)
Hellberg, A., et al. Br. J. Haematol. 125(4):528-536(2004)
Hellberg, A., et al. J. Biol. Chem. 277(33):29455-29459(2002)
Okajima, T., et al. J. Biol. Chem. 275(51):40498-40503(2000)
Amado, M., et al. Biochim. Biophys. Acta 1473(1):35-53(1999)
Amado, M., et al. J. Biol. Chem. 273(21):12770-12778(1998)
Almeida, R., et al. J. Biol. Chem. 272(51):31979-31991(1997)
Taniguchi, N., et al. J. Biol. Chem. 259(9):5637-5642(1984)