BACE Antibody (S498) Blocking Peptide
€293.00
In stock
SKU
AC-BP7774a
Background:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
Other Names: Beta-secretase 1, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE1, BACE, KIAA1149
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7774a was selected from the S498 region of human BACE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: P56817
Gene ID: 23621
Gene Name: BACE1 (HGNC:933)
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Xie, J., et al., J. Biol. Chem. 280(14):13824-13832 (2005).He, X., et al., J. Biol. Chem. 280(12):11696-11703 (2005).Huang, X.P., et al., J. Biol. Chem. 279(36):37886-37894 (2004).Chiocco, M.J., et al., J. Biol. Chem. 279(50):52535-52542 (2004).Yang, H.C., et al., J. Neurochem. 91(6):1249-1259 (2004).
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
Other Names: Beta-secretase 1, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE1, BACE, KIAA1149
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7774a was selected from the S498 region of human BACE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: P56817
Gene ID: 23621
Gene Name: BACE1 (HGNC:933)
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Xie, J., et al., J. Biol. Chem. 280(14):13824-13832 (2005).He, X., et al., J. Biol. Chem. 280(12):11696-11703 (2005).Huang, X.P., et al., J. Biol. Chem. 279(36):37886-37894 (2004).Chiocco, M.J., et al., J. Biol. Chem. 279(50):52535-52542 (2004).Yang, H.C., et al., J. Neurochem. 91(6):1249-1259 (2004).
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