BAG5 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61560
Background:
Bag-5 (Bcl-2-associated athanogene 5),also known as Bag family molecular chaperone regulator 5,is a member of the Bag family of proteins and contains four Bag domains.Via their Bag domain, Bag proteins bind with high affinity to the HSC 70/HSP 70 ATPase domain, regulating chaperone activity and apoptosis.Bag-5 is a component of the HSP 70/Parkin complex and acts to inhibit Parkin E3 ubiquitin ligase activity and HSP 70 chaperone activity. In this complex, Bag-5 directly interacts with the ATPase domain of HSP 70 and the N-terminal linker region of Parkin. Bag-5 expression is induced upon dopaminergic neuron injury and functions to sensitize the neurons to injuryinduced cell death. In addition, Bag-5 may be a useful target in therapies for neurodegenerative diseases such as Parkinson’s disease which is caused by a mutation in the gene encoding Parkin.
Alternative Name:
BAG family molecular chaperone regulator 5, BAG-5, Bcl-2-associated athanogene 5
Application Dilution: WB: 1:500~1:1000
Specificity: BAG5 polyclonal antibody detects endogenous levels of BAG5 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 11-55 of Human BAG5
MW: ~ 51 kDa
Swis Prot.: Q9UL15
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Bag-5 (Bcl-2-associated athanogene 5),also known as Bag family molecular chaperone regulator 5,is a member of the Bag family of proteins and contains four Bag domains.Via their Bag domain, Bag proteins bind with high affinity to the HSC 70/HSP 70 ATPase domain, regulating chaperone activity and apoptosis.Bag-5 is a component of the HSP 70/Parkin complex and acts to inhibit Parkin E3 ubiquitin ligase activity and HSP 70 chaperone activity. In this complex, Bag-5 directly interacts with the ATPase domain of HSP 70 and the N-terminal linker region of Parkin. Bag-5 expression is induced upon dopaminergic neuron injury and functions to sensitize the neurons to injuryinduced cell death. In addition, Bag-5 may be a useful target in therapies for neurodegenerative diseases such as Parkinson’s disease which is caused by a mutation in the gene encoding Parkin.
Alternative Name:
BAG family molecular chaperone regulator 5, BAG-5, Bcl-2-associated athanogene 5
Application Dilution: WB: 1:500~1:1000
Specificity: BAG5 polyclonal antibody detects endogenous levels of BAG5 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 11-55 of Human BAG5
MW: ~ 51 kDa
Swis Prot.: Q9UL15
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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