BAI1 Antibody (C-term) Blocking Peptide
€293.00
In stock
SKU
AC-BP8170a
Background:
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.
Other Names: Brain-specific angiogenesis inhibitor 1, BAI1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8170a was selected from the C-term region of human BAI1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: O14514
Other Accession: BAI1_HUMAN
Gene ID: 575
Gene Name: ADGRB1 (HGNC:943)
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Kaur, B., et al., Am. J. Pathol. 162(1):19-27 (2003).Mori, K., et al., Neurosci. Res. 43(1):69-74 (2002).Duda, D.G., et al., Br. J. Cancer 86(3):490-496 (2002).Shiratsuchi, T., et al., Biochem. Biophys. Res. Commun. 247(3):597-604 (1998).Fukushima, Y., et al., Int. J. Oncol. 13(5):967-970 (1998).
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.
Other Names: Brain-specific angiogenesis inhibitor 1, BAI1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8170a was selected from the C-term region of human BAI1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: O14514
Other Accession: BAI1_HUMAN
Gene ID: 575
Gene Name: ADGRB1 (HGNC:943)
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Kaur, B., et al., Am. J. Pathol. 162(1):19-27 (2003).Mori, K., et al., Neurosci. Res. 43(1):69-74 (2002).Duda, D.G., et al., Br. J. Cancer 86(3):490-496 (2002).Shiratsuchi, T., et al., Biochem. Biophys. Res. Commun. 247(3):597-604 (1998).Fukushima, Y., et al., Int. J. Oncol. 13(5):967-970 (1998).
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