BAP1 (clone BP-1), anti-human

Protein Family: Enzymes, Ubiquitins, Peptidases

Pathway and Disease: Transcription

Description:
BRCA1-associated protein 1 (BAP1) is a deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. BAP1 interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. BAP1 however does not mediate deubiquitination of BRCA1 and BARD1. BAP1 also acts as a tumor suppressor.

Alternate Names: Ubiquitin carboxyl-terminal hydrolase BAP1, BRCA1-associated protein 1, Cerebral protein 6, BAP1, KIAA0272, hucep-6

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500

Accession No.: Q92560

Antigen: Recombinant full-length BAP1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.