Bax (clone ), anti-human, mouse
€428.00
In stock
SKU
MB9013
Background:
The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 is localized to outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes. A related protein, designated Bax p21 (for Bcl-associated X protein), has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.
Alternative Name:
Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX, BCL2L4
Application Dilution: WB: 1:500, ICC: 1:200, IHC: 1:200 FC: 1:50
Specificity: This antibody detects endogenous levels of Bax and does not cross-react with related proteins.
Immunogen:
This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to N-terminal Bax.
MW: ~ 21 kDa
Swis Prot.: Q07812
Purification & Purity:
Protein A affinity purified
Format:
Mouse IgA. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 is localized to outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes. A related protein, designated Bax p21 (for Bcl-associated X protein), has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.
Alternative Name:
Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX, BCL2L4
Application Dilution: WB: 1:500, ICC: 1:200, IHC: 1:200 FC: 1:50
Specificity: This antibody detects endogenous levels of Bax and does not cross-react with related proteins.
Immunogen:
This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to N-terminal Bax.
MW: ~ 21 kDa
Swis Prot.: Q07812
Purification & Purity:
Protein A affinity purified
Format:
Mouse IgA. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review