BBOX1 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS7873
Background:
BBOX1 (butyrobetaine (γ), 2-oxoglutarate dioxygenase 1), also known as BBH, BBOX, G-BBH (γ-butyrobetaine hydroxylase) or γ-BBH, is a member of the γ-BBH/TMLD family of proteins. Localizing to the cytoplasm and predominantly expressed in kidney, BBOX1 plays a role in the biosynthesis of amines, polyamines and carnitines. More specifically, BBOX1 catalyzes the hydroxylation of γ-butyrobetaine to L-carnitine, a reaction that requires iron and ascorbate as cofactors. This is the last of five steps comprising the L-carnitine biosynthesis pathway and it is important for the proper transport of activated fatty acids across the mitochondrial membrane. Coupled to this reaction, BBOX1 simultaneously catalyzes the oxidative decarboxylation of α-ketoglutarate to succinate.
Alternative Name:
2-oxoglutarate dioxygenase, BBH, BBOX 1, BBOX, Bbox1, BODG_HUMAN, Butyrobetaine (gamma) 2 oxoglutarate dioxygenase (gamma butyrobetaine hydroxylase) 1, G BBH, Gamma BBH, Gamma butyrobetaine 2 oxoglutarate dioxygenase 1, Gamma butyrobetaine dioxygenase, Gamma butyrobetaine hydroxylase, Gamma-BBH, Gamma-butyrobetaine, Gamma-butyrobetaine dioxygenase, Gamma-butyrobetaine hydroxylase
Application Dilution: WB: 1:500~1:2000
Specificity: BBOX1 polyclonal antibody detects endogenous levels of BBOX1 protein.
Immunogen:
Recombinant full length Human BBOX1.
MW: ~ 45 kDa
Swis Prot.: O75936
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
BBOX1 (butyrobetaine (γ), 2-oxoglutarate dioxygenase 1), also known as BBH, BBOX, G-BBH (γ-butyrobetaine hydroxylase) or γ-BBH, is a member of the γ-BBH/TMLD family of proteins. Localizing to the cytoplasm and predominantly expressed in kidney, BBOX1 plays a role in the biosynthesis of amines, polyamines and carnitines. More specifically, BBOX1 catalyzes the hydroxylation of γ-butyrobetaine to L-carnitine, a reaction that requires iron and ascorbate as cofactors. This is the last of five steps comprising the L-carnitine biosynthesis pathway and it is important for the proper transport of activated fatty acids across the mitochondrial membrane. Coupled to this reaction, BBOX1 simultaneously catalyzes the oxidative decarboxylation of α-ketoglutarate to succinate.
Alternative Name:
2-oxoglutarate dioxygenase, BBH, BBOX 1, BBOX, Bbox1, BODG_HUMAN, Butyrobetaine (gamma) 2 oxoglutarate dioxygenase (gamma butyrobetaine hydroxylase) 1, G BBH, Gamma BBH, Gamma butyrobetaine 2 oxoglutarate dioxygenase 1, Gamma butyrobetaine dioxygenase, Gamma butyrobetaine hydroxylase, Gamma-BBH, Gamma-butyrobetaine, Gamma-butyrobetaine dioxygenase, Gamma-butyrobetaine hydroxylase
Application Dilution: WB: 1:500~1:2000
Specificity: BBOX1 polyclonal antibody detects endogenous levels of BBOX1 protein.
Immunogen:
Recombinant full length Human BBOX1.
MW: ~ 45 kDa
Swis Prot.: O75936
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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