BBS10 Antibody (C-term) Blocking Peptide
€293.00
In stock
SKU
AC-BP4880b
Background:
BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.
Other Names: Bardet-Biedl syndrome 10 protein, BBS10, C12orf58
Type: Synthetic peptide
Primary Accession: Q8TAM1
Gene ID: 79738
Gene Name: BBS10
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Marion, V., et al. Proc. Natl. Acad. Sci. U.S.A. 106(6):1820-1825(2009)Gerth, C., et al. Vision Res. 48(3):392-399(2008)White, D.R., et al. Eur. J. Hum. Genet. 15(2):173-178(2007)
BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.
Other Names: Bardet-Biedl syndrome 10 protein, BBS10, C12orf58
Type: Synthetic peptide
Primary Accession: Q8TAM1
Gene ID: 79738
Gene Name: BBS10
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Marion, V., et al. Proc. Natl. Acad. Sci. U.S.A. 106(6):1820-1825(2009)Gerth, C., et al. Vision Res. 48(3):392-399(2008)White, D.R., et al. Eur. J. Hum. Genet. 15(2):173-178(2007)
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