BCL-10 (clone 4F8), anti-human, mouse
€346.00
In stock
SKU
252596
Catalog Nr.: 252596
Size: 0.1 mg
Isotype: Mouse IgG1
Applications: E, WB, IHC, IF, FC
Size: 0.1 mg
Isotype: Mouse IgG1
Applications: E, WB, IHC, IF, FC
Protein Family: Chaperones and Folding Catalysts
Pathway and Disease: Immune System, Infectious Diseases
Description:
Bcl-10 (B-cell CLL/lymphoma 10) is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappa. Bcl-10 interacts with CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Alternate Names: Bcl-10, B-cell lymphoma/leukemia 10, B-cell CLL/lymphoma 10, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, CARD-containing molecule enhancing NF-kappa-B, Cellular homolog of vCARMEN, cCARMEN, Mammalian CARD-containing adapter molecule E10, mE10, Cellular-E10, c-E10, CARD-like apoptotic protein, hCLAP, BCL10, CIPER, CLAP
Application Notes: E: 1:10000; WB: 1:500-1:2000; IHC: 1:200-1:1000; IF: 1:200-1:1000; FC: 1:200-1:400
Accession No.: O95999
Antigen: Purified recombinant fragment of human BCL-10 expressed in E. coli.
Format: Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Immune System, Infectious Diseases
Description:
Bcl-10 (B-cell CLL/lymphoma 10) is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappa. Bcl-10 interacts with CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Alternate Names: Bcl-10, B-cell lymphoma/leukemia 10, B-cell CLL/lymphoma 10, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, CARD-containing molecule enhancing NF-kappa-B, Cellular homolog of vCARMEN, cCARMEN, Mammalian CARD-containing adapter molecule E10, mE10, Cellular-E10, c-E10, CARD-like apoptotic protein, hCLAP, BCL10, CIPER, CLAP
Application Notes: E: 1:10000; WB: 1:500-1:2000; IHC: 1:200-1:1000; IF: 1:200-1:1000; FC: 1:200-1:400
Accession No.: O95999
Antigen: Purified recombinant fragment of human BCL-10 expressed in E. coli.
Format: Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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