BCL-10 (clone EBS-T-001), anti-human

Source:
A BALB/c mouse was immunized with human BCL10 recombinant protein (aa122-168).
Fusion partner: SP2/0.

Specifications:
EBS-T-001 reacts with BCL10. Having an N-terminal caspase recruitment domain (CARD), BCL10 can induce apoptosis and activate NF-B. It is found on subpopulations of normal B and T cells, and is associated with MALT1, a paracaspase that, like BCL10, can be found translocated in MALT lymphoma. In such cases either BCL10 or MALT1 or both are highly expressed, depending on the site of translocation. MALT lymphomas lackingthis translocation exhibit much lower levels of expression. BCL10 has been shown to be functionally conserved all the way back to zebrafish.

Species reactivity:
Positive: human.

Applications:
EBS-T-001 is excellent for immunohistochemistry on paraffin sections and for western blot. Other applications not tested.
Frozen sections: +
Paraffin sections: Citrate
Western blot: +

Positive control: HepG2 cells or lymphoma.

References:
- Ye H, et al, Am J Pathol157: 1147-54 (2000).