Bcl-2 (clone ), anti-human
€362.00
In stock
SKU
251711
Catalog Nr.: 251711
Size: 0.1 mg
Isotype: Mouse IgG1
Applications: E, WB, IHC; ICC
Size: 0.1 mg
Isotype: Mouse IgG1
Applications: E, WB, IHC; ICC
Protein Family: Chaperones and Folding Catalysts
Pathway and Disease: Folding, Sorting and Degradation, Cell Growth and Death, Cell Communication, Nervous and Sensory Systems, Neurodegenerative Disorders, Cancers, Infectious Diseases
Description:
Apoptosis regulator Bcl-2 (Bcl-2) suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 regulates cell death by controlling mitochondrial membrane permeability. Bcl-2 functions in a feedback loop system with caspases, inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). A chromosomal aberration involving Bcl-2 has been found in chronic lymphatic leukemia.
Alternate Names: Apoptosis regulator Bcl-2, BCL2
Application Notes: E: 1:500-1:1,000; WB: 1:50-1:200; IHC: 1:100-1:250; ICC: 1:100-1:250
Accession No.: P10415
Antigen: Thyroglobulin-conjugated synthetic peptide encompassing a sequence within the N-term region of human Blcl-2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Wu Q et al. 2011. Journal of Ethnopharmacology. 38(1):34-39. PMID# 21856397.
Pathway and Disease: Folding, Sorting and Degradation, Cell Growth and Death, Cell Communication, Nervous and Sensory Systems, Neurodegenerative Disorders, Cancers, Infectious Diseases
Description:
Apoptosis regulator Bcl-2 (Bcl-2) suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 regulates cell death by controlling mitochondrial membrane permeability. Bcl-2 functions in a feedback loop system with caspases, inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). A chromosomal aberration involving Bcl-2 has been found in chronic lymphatic leukemia.
Alternate Names: Apoptosis regulator Bcl-2, BCL2
Application Notes: E: 1:500-1:1,000; WB: 1:50-1:200; IHC: 1:100-1:250; ICC: 1:100-1:250
Accession No.: P10415
Antigen: Thyroglobulin-conjugated synthetic peptide encompassing a sequence within the N-term region of human Blcl-2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Wu Q et al. 2011. Journal of Ethnopharmacology. 38(1):34-39. PMID# 21856397.
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