Beta-Amyloid [1-42] polyclonal, anti-human, mouse, rat
€402.00
In stock
SKU
250924
Catalog Nr.: 250924
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: WB, IHC, E
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: WB, IHC, E
Protein Family: Proteoglycans
Pathway and Disease: Neurodegenerative Disorders
Description:
Beta-amyloid production results from cleavage in the extracellular domain of APP by the beta-secretase (BACE1) , which results in the production of the APP C-terminal fragment C99. This fragment is further cleaved by the gamma-secretase at residues 40-42 to produce beta-amyloid 40 and 42 peptides. Beta-amyloid aggregation and neuritic plaque formation are pathologic hallmarks of Alzheimer disease. This fragment is the amino terminus (1-42) of beta-amyloid.
Alternate Names: APP, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA7
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P05067
Antigen: KLH-conjugated synthetic peptide encompassing the sequence (1-42) of human Beta Amyloid.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Morkuniene R et al. 2013. Journal of Neurochemistry. 126(5): 604-15. PMID# 23745639.
Pathway and Disease: Neurodegenerative Disorders
Description:
Beta-amyloid production results from cleavage in the extracellular domain of APP by the beta-secretase (BACE1) , which results in the production of the APP C-terminal fragment C99. This fragment is further cleaved by the gamma-secretase at residues 40-42 to produce beta-amyloid 40 and 42 peptides. Beta-amyloid aggregation and neuritic plaque formation are pathologic hallmarks of Alzheimer disease. This fragment is the amino terminus (1-42) of beta-amyloid.
Alternate Names: APP, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA7
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P05067
Antigen: KLH-conjugated synthetic peptide encompassing the sequence (1-42) of human Beta Amyloid.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Morkuniene R et al. 2013. Journal of Neurochemistry. 126(5): 604-15. PMID# 23745639.
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