Beta-ARK-1 polyclonal, anti-human, mouse, rat
€362.00
In stock
SKU
251577
Catalog Nr.: 251577
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Immune System, Nervous and Sensory Systems
Description:
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Beta-ARK-1 is a key regulator of LPAR1 signaling. Beta-ARK-1 competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Beta-ARK-1 desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Beta-ARK-1 is expressed in peripheral blood leukocytes.
Alternate Names: Beta-ARK-1, Beta-adrenergic receptor kinase 1, G-protein coupled receptor kinase 2, GRK2, ADRBK1, BARK, BARK1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P25098
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Beta-ARK-1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Immune System, Nervous and Sensory Systems
Description:
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Beta-ARK-1 is a key regulator of LPAR1 signaling. Beta-ARK-1 competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Beta-ARK-1 desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Beta-ARK-1 is expressed in peripheral blood leukocytes.
Alternate Names: Beta-ARK-1, Beta-adrenergic receptor kinase 1, G-protein coupled receptor kinase 2, GRK2, ADRBK1, BARK, BARK1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P25098
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Beta-ARK-1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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