Beta-arrestin 1/2 polyclonal, anti-human, mouse, rat, monkey, bovine

Protein Family: Receptors and Channels, Transporters

Pathway and Disease: Signal Transduction, Immune System

Description:
Beta-arrestins function in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein. Beta-arrestin binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adaptor protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). This antibody recognizes beta-arrestin-1 and beta-arrestin-2. The extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type.

Alternate Names: beta-arrestin 1, beta-arrestin 2, beta-arrestin 1/2, Beta-arrestin-1/2, Beta-arrestin-1, Arrestin beta-1, ARRB1, Beta-arrestin-2, Arrestin beta-2, ARRB2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P49407; P32121

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human beta-arrestin 1/2.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.