beta Tubulin Polyclonal Antibody

Background:
TUBB3, the class III β tubulin or Tuj1, is selectively expressed in testis and neurons of the central and peripheral nervous system. It has been widely used as a marker for neurons. Aberrant expression of TUBB3 has also been found in various tumors of non-neural origin and can be used as a biomarker for cancer aggressiveness and a marker for the tendency to respond poorly to chemotherapy. This antibody is specific to TUBB3 but not cross-react with other tubulin isoforms.

Research Area: Cancer, Neuroscience, Signal Transduction, Tags and Cell Markers

Synonyms:
beta 3 tubulin, beta-4, CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, M(beta)3, M(beta)6, MC1R, Neuron specific beta III Tubulin, Neuron-specific class III beta-tubulin, QccE-11995, QccE-15186, TBB3, Tubb 3, TUBB3, TUBB4, Tubulin beta 3, Tubulin beta 3 chain, Tubulin beta 4, Tubulin beta III, Tubulin beta-3 chain, Tubulin beta-4 chain, Tubulin beta-III

Immunogen: Synthesized peptide derived from the C-terminal region of mouse Tubulin β

Swissprot: Q13509

Calculated MW: 50 kDa
Observed MW: 55 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://pubs.acs.org/doi/abs/10.1021/acschemneuro.8b00680
https://www.ncbi.nlm.nih.gov/pubmed/32090027
https://pubmed.ncbi.nlm.nih.gov/32692841/