Bim (clone 1C2H4), anti-human, mouse, rat

Protein Family: Chaperones and Folding Catalysts

Pathway and Disease: Folding, Sorting and Degradation, Cell Growth and Death, Cell Communication, Nervous and Sensory Systems, Neurodegenerative Disorders, Cancers, Infectious Diseases

Description:
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim is another BH3 domain containing protein which can induce apoptosis. Bim interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.

Alternate Names: Bim, Bcl-2 interacting protein, Bcl-2-related ovarian death gene, BOD, Bcl-2-like 11

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500

Accession No.: NP_619527

Antigen: Amino acids 2 to 198 of human Bim.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.02% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at 4°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.