BIN1 (clone BN-1), anti-human, mouse, rat

Protein Family: Chaperones and Folding Catalysts

Pathway and Disease: Signaling Molecules and Interaction, Membrane Transport

Description:
Box-dependent myc-interacting protein 1 (BIN1) is involved in regulation of synaptic vesicle endocytosis. BIN1 acts as a tumor suppressor and inhibits malignant cell transformation. Defects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM), also known as autosomal recessive myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles.

Alternate Names: BIN1, Myc box-dependent-interacting protein 1, Bridging integrator 1, Amphiphysin-like protein, Amphiphysin II, Box-dependent myc-interacting protein 1, AMPHL

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; ICC: 1:100-1:500

Accession No.: O00499

Antigen: Recombinant polypeptide encompassing the center region of human BIN1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.